Peptides

A 29-amino-acid fragment of growth hormone-releasing hormone (GHRH) that stimulates the pituitary to release the body's own growth hormone. Once an FDA-approved drug for pediatric growth hormone deficiency, it is now mostly used off-label and compounded for adult anti-aging and GH-optimization protocols.

Muscle / GH axis · Longevity / aging

A mitochondria-derived peptide researched for metabolic regulation and exercise-related stress responses. Still early relative to incretin drugs, but frequently searched in biohacking circles.

Metabolic · Fat loss · Recovery · Longevity / aging

A 28-amino-acid immunomodulatory peptide, marketed in dozens of countries as Zadaxin/thymalfasin for chronic viral hepatitis and as an immune-response adjunct in cancer and infection. One of the few peptides in this space with genuine international drug-approval history.

Immune support · Longevity / aging

A mitochondria-targeted peptide that stabilizes cardiolipin in the inner mitochondrial membrane, supporting energy production and reducing oxidative stress. FDA-approved as elamipretide for Barth syndrome, a rare genetic mitochondrial disease, and one of the few peptides in this category with an actual regulatory approval.

Longevity / aging · Recovery

A 24-amino-acid peptide encoded within mitochondrial DNA itself, part of a growing family of "mitochondrial-derived peptides" (alongside MOTS-c) studied in aging and cellular-stress biology.

Longevity / aging

A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in fat-cell metabolism and NAD+ regulation. Reduced fat mass in diet-induced-obese mice without affecting food intake, but has never been tested in a published human clinical trial.

Fat loss · Metabolic · Longevity / aging

A synthetic tetrapeptide associated with pineal peptide research and aging biology conversations. Evidence is largely historical/preclinical with limited modern RCT coverage.

Longevity / aging · Sleep / recovery adjunct · Recovery

A complex of polypeptides extracted from calf thymus tissue, used clinically in Russia since the 1970s as an immune-modulating and geroprotective agent. Backed mainly by Russian-language research from a single research institute, without independent replication in Western trials.

Immune support · Longevity / aging

A lab-designed "D-retro-inverso" peptide built to disrupt one specific protein-protein interaction that keeps aged cells alive, making it a purpose-built senolytic rather than a naturally occurring hormone fragment. Widely cited in longevity media as the "reverse aging in mice" peptide.

Longevity / aging